MedTrace Logo

Negative Emotionality and Epigenetics During Puberty

NCT06690866 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2024-11-15

No results posted yet for this study

Summary

Pubertal transition leads to enduring neuroendocrine changes along with changes in the epigenome. The prevalence of psychiatric disorders significantly increases in females compared to males after puberty. There is likely to be an interaction between epigenetics, hormones and neurophysiological processes during puberty, leading to the increased prevalence of mental disorders in females. This study aims to shed light on these interactions underlying the emerging sex differences after puberty. Specifically, it seeks to investigate the epigenetic modifications and subsequent changes in gene expression during the pubertal transition and their association with negative emotionality (e.g., acute stress response and depressive symptoms) at molecular, neuronal, subjective and physiological levels.

Conditions

  • Puberty
  • Healthy
  • Stress

Interventions

BEHAVIORAL

Stress

Montreal Imaging Stress Task is a stress paradigm in the scanner to examine neuronal correlates of acute psychosocial stress.

Sponsors & Collaborators

  • University Hospital Tuebingen

    collaborator OTHER

  • Uppsala University

    collaborator OTHER

  • German Research Foundation

    collaborator OTHER

  • International Research Training Group 2804

    lead OTHER

Principal Investigators

  • Vanessa Nieratschker, Prof. · University Hospital Tuebingen

  • Mirac Nur Musaoglu, MD · University Hospital Tuebingen

Eligibility

Min Age
8 Years
Max Age
17 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-03-26
Primary Completion
2025-12-31
Completion
2026-04-30

Countries

  • Germany

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06690866 on ClinicalTrials.gov