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Brain Blood Vessel Responses to Changes in Blood Flow

NCT06629077 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2026-03-02

No results posted yet for this study

Summary

Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.

Conditions

  • Magnetic Resonance Imaging
  • Cerebrovascular Circulation

Interventions

DEVICE

MRI

Participants will undergo an MRI scan while performing breathing and a simulated postural change task.

DRUG

Prazosin

A dose of prazosin will be administered based on body weight.

DRUG

Placebo

Oral placebo

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    collaborator NIH

  • University of Wisconsin, Madison

    lead OTHER

Principal Investigators

  • Jill Barnes, PhD · UW Madison

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
55 Years
Max Age
69 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-02-26
Primary Completion
2027-01-31
Completion
2027-01-31
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06629077 on ClinicalTrials.gov