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Assessment of Cholinergic and Cognitive Function Using Pharmacologic ASL-Perfusion MRI

NCT01379001 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2013-01-04

No results posted yet for this study

Summary

This research study will look at how medications affect the pattern of blood flow in the brain. This study will use a special type of MRI (magnetic resonance imaging) scan called perfusion MRI to make measurements of cerebral (brain) blood flow. The medications we will use in this study are scopolamine (commonly used to treat motion sickness), mecamylamine (used to treat high blood pressure), and donepezil (used to treat memory loss). Cognitive testing will also be obtained, and correlated with the blood flow patterns in the brain.

Conditions

  • Cholinergic Function

Interventions

DRUG

Scopolamine

Scopolamine 0.4mg IM x 1 dose; adjustment in older group for weight (0.4mg/70kg)

DRUG

Placebo

IM or PO placebo

DRUG

Donepezil

donepezil 5mg PO x 1

Sponsors & Collaborators

  • Hebrew SeniorLife

    lead OTHER

Principal Investigators

  • Tamara Fong, MD · Hebrew Rehabilitation Center

Study Design

Allocation
RANDOMIZED
Masking
DOUBLE
Model
SINGLE_GROUP

Eligibility

Min Age
21 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-07-31
Primary Completion
2013-01-31
Completion
2013-01-31

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01379001 on ClinicalTrials.gov