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Evaluation of Bone Metabolism in Children and Adolescents With Familial Mediterranean Fever

NCT06034795 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 62

Last updated 2023-09-13

No results posted yet for this study

Summary

Familial Mediterranean Fever is a chronic auto-inflammatory disease. In the context of chronic inflammation, it seems that, among others, it also affects bone density in children. Bone loss may be due to subclinical inflammation that persists even during periods of remission. In addition, inflammatory cytokines also play an important role (mainly during episodes) resulting in an increase in bone degradation and ultimately a reduction in bone mass. Cytokines mainly associated with bone degradation and osteoclast activity are: IL-1R, IL-2, IL-6, IL-8, TNFa.

The purpose of this study is to determine the effect of FMF on bone density and to compare the results with a healthy population. In addition, the difference between the children with FMF will be studied according to the mutation they carry.

Conditions

  • Familial Mediterranean Fever

Sponsors & Collaborators

  • Papageorgiou General Hospital

    collaborator OTHER

  • Aristotle University Of Thessaloniki

    lead OTHER

Principal Investigators

  • Maria Fotoulaki, Professor · Papageorgiou General Hospital

  • Effimia Papadopoulou, Professor · Papageorgiou General Hospital

  • Christina Chaintari, Pediatrician · Papageorgiou General Hospital

  • Assimina Galli, Professor · AHEPA General Hospital

Eligibility

Min Age
6 Years
Max Age
20 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-01-08
Primary Completion
2024-01-31
Completion
2025-01-31

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06034795 on ClinicalTrials.gov