Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell Carcinoma
NCT06567314 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 24
Last updated 2026-04-20
Summary
To learn if ivonescimab can help to control advanced cSCC. The safety and effects of ivonescimab will also be studied.
Conditions
Interventions
- DRUG
-
Given by PO
Sponsors & Collaborators
-
Summit Therapeutics
collaborator INDUSTRY -
M.D. Anderson Cancer Center
lead OTHER
Principal Investigators
-
Aung Naing, MD · M.D. Anderson Cancer Center
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-12-02
- Primary Completion
- 2028-09-01
- Completion
- 2030-09-01
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Neoadjuvant Pembrolizumab in Cutaneous Squamous Cell Carcinoma
NCT05025813 ·Status: RECRUITING ·Phase: PHASE2
-
Physician/Patient Choice of Either High-Dose Recombinant Interferon Alfa-2B or Ipilimumab, Versus Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery
NCT02506153 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Microneedle Array Plus Doxorubicin in Cutaneous Squamous Cell Cancer (cSCC)
NCT05377905 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Nivolumab in Patients With Advanced Cutaneous Squamous Cell Carcinoma
NCT03834233 ·Status: UNKNOWN ·Phase: PHASE2
-
Symptoms of Immune Checkpoint Inhibitor Therapy in Cutaneous Melanoma
NCT07148245 ·Status: RECRUITING
-
Neoadjuvant Immunotherapy With Tavo + Electroporation in Combination With Nivo. in Melanoma Patients
NCT04526730 ·Status: COMPLETED ·Phase: PHASE2
-
Dose-escalation Study of Combination BMS-936558 (MDX-1106) and Ipilimumab in Subjects With Unresectable Stage III or Stage IV Malignant Melanoma
NCT01024231 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate Whether Participants With Melanoma Prefer Subcutaneous vs Intravenous Administration of Nivolumab and Nivolumab + Relatlimab Fixed-dose Combinations
NCT06101134 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Study of Cemiplimab in Patients With Type of Skin Cancer Stage II to IV Cutaneous Squamous Cell Carcinoma
NCT04154943 ·Status: COMPLETED ·Phase: PHASE2
-
4SC-202 in Combination With Pembrolizumab in Patients Primary Refractory/Non-responding to Prior Anti-PD-1 Therapy
NCT03278665 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Ipilimumab vs Ipilimumab Plus Nivolumab in Patients With Stage III-IV Melanoma Who Have Progressed or Relapsed on PD-1 Inhibitor Therapy
NCT02731729 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Intratumoral CV8102 in cMEL, cSCC, hnSCC, and ACC
NCT03291002 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study of Combination Treatment With HF10 and Ipilimumab in Patients With Unresectable or Metastatic Melanoma
NCT02272855 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Pembrolizumab as First Line Therapy in Patients With Unresectable Squamous Cell Carcinoma of the Skin
NCT02883556 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase 1b Study of the Selective HDAC Inhibitor Mocetinostat in Combination With Ipilimumab and Nivolumab in Patients With Unresectable Stage III or Stage IV Melanoma
NCT03565406 ·Status: TERMINATED ·Phase: PHASE1
-
CP-461 in the Treatment of Patients With Advanced Melanoma
NCT00060710 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of ONCOS-102 in Combination With Other Novel Immune-therapies in Advanced Treatment-resistant Melanoma Patients
NCT05561491 ·Status: WITHDRAWN ·Phase: PHASE2
-
Immunotherapy With Autologous Dexosomes for Patients With Stage IV Melanoma
NCT00042497 ·Status: SUSPENDED ·Phase: PHASE2
-
Irofulven in Treating Patients With Stage IV Melanoma
NCT00005968 ·Status: COMPLETED ·Phase: PHASE2
-
IL2 With Ipilimumab Followed by Nivolumab in Stage 3 or 4 Melanoma Patients
NCT04562129 ·Status: RECRUITING ·Phase: PHASE2
-
Biological Outcomes of Pramlintide in Resectable Cutaneous Squamous Cell Carcinoma: A Pilot Study
NCT04252612 ·Status: WITHDRAWN ·Phase: EARLY_PHASE1
-
Study of Combination of Ipilimumab and Nivolumab in Patients With Melanoma
NCT02970981 ·Status: COMPLETED ·Phase: PHASE2
-
Nivolumab/Ipilimumab Plus Cabozantinib in Patients With Unresectable Advanced Melanoma
NCT04091750 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of (Neo)Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Cutaneous Squamous Cell Carcinoma (V940-007)
NCT06295809 ·Status: TERMINATED ·Phase: PHASE2/PHASE3
-
L19IL2/L19TNF in Patients With Cutaneous Squamous Cell Carcinoma
NCT07228442 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2