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Mini Crush or Double Kissing Crush Stenting Techniques For Complex Left Main Bifurcation Lesions

NCT06546748 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 531

Last updated 2025-03-18

No results posted yet for this study

Summary

The Crush technique has evolved significantly since its introduction to the literature by Colombo et al in 2003, with multiple iterations including mini-crush (MC) and double kissing-crush (DKC) stenting techniques. The main principle of crush techniques for complex bifurcation lesions is to protrude the side branch (SB) stent towards the main branch to adequately cover the SB ostium and minimize the risk of SB ostium restenosis. It was noticed that the 4-5 mm protrusion of the SB stent resulted in a large volume of the crushed stent and the technique was modified into MC which aimed for approximately 1-2 mm protrusion by Galassi et al in 2007. Despite all the disadvantages of the crush technique, the final kissing balloon inflation (KBI) rate of this technique, along with several iterations has been up to 98%. Moreover, a recent meta-analysis showed that MC was associated with a reduction in risk of major cardiovascular events compared to provisional stenting, crush, and culotte techniques. The DKC is a planned 2-stent technique introduced by Chen et al. The ultimate innovation of this approach is that it is designed to increase the success rate of the final KBI. Provided recrossing of the crushed stent occurs through the proximal cell: another advantage of the DKC technique is to improve the success of KBI. The DKC significantly reduced major cardiovascular events (MACE) compared to provisional stenting, crush, TAP, and culotte. Until now, no clinical investigation has compared the DKC and MC in patients with complex left main bifurcation lesions. Therefore, this study sought to determine the clinical results of DKC and MC stenting techniques under long-term follow-up.

Conditions

  • Left Main Coronary Artery Disease

Sponsors & Collaborators

  • Koşuyolu Kartal Heart Training and Research Hospital

    collaborator OTHER

  • Basaksehir Cam & Sakura City Hospital

    collaborator UNKNOWN

  • Medipol University

    collaborator OTHER

  • Sisli Hamidiye Etfal Training and Research Hospital

    collaborator OTHER

  • Bağcılar Training and Research Hospital

    collaborator UNKNOWN

  • Ankara Etlik City Hospital

    collaborator OTHER_GOV

  • Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital

    collaborator OTHER

  • Istanbul Mehmet Akif Ersoy Educational and Training Hospital

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-07-22
Primary Completion
2024-10-30
Completion
2024-10-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06546748 on ClinicalTrials.gov