Personalised Immunotherapy Platform
NCT06536257 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1000
Last updated 2025-09-18
Summary
This is a non-interventional study to prospectively test a suite of predictive biomarker models of immunotherapy resistance in patients with melanoma, non-melanoma skin cancers and other solid tumours. The study will evaluate the documentation, processes, accuracy and utility of the predictive biomarker model in clinical practice.
Conditions
Interventions
- OTHER
-
Predictive model
Patient who have not had immunotherapy will have tumour tested using the predictive model. This determines whether patients are likely to respond, or not to respond to immunotherapy. Results of the predictive model will be compared with the actual response to immunotherapy when this has been completed.
Sponsors & Collaborators
-
Melanoma Institute Australia
lead OTHER
Principal Investigators
-
James Wilmott, PhD · Melanoma Institute Australia
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-06-08
- Primary Completion
- 2027-06-01
- Completion
- 2037-06-01
Countries
- Australia
Study Locations
More Related Trials
-
PV-10 in Combination With Pembrolizumab for Treatment of Metastatic Melanoma
NCT02557321 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
A Platform Study of Novel Immunotherapy Products in Participants With Previously Treated Unresectable or Metastatic Cutaneous Melanoma
NCT05572463 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Biomarkers for the Activity of Immune Checkpoint Inhibitor Therapy in Patients With Advanced Melanoma
NCT02673970 ·Status: RECRUITING
-
Imiquimod and Pembrolizumab in Treating Patients With Stage IIIB-IV Melanoma
NCT03276832 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Study to Compare the Effect of Ipilimumab Retreatment With That of Chemotherapy in Advanced Melanoma
NCT01709162 ·Status: TERMINATED ·Phase: PHASE2
-
Profiling of Circulating Immune Cells to Uncover Response Signatures to Anti-PD1 Immunotherapy in Melanoma Patients
NCT06154668 ·Status: RECRUITING
-
Immunotherapy +/- EGFR Inhibitor In Advanced/Metastatic cSCC: Tackling Primary And Secondary Resistance
NCT03666325 ·Status: UNKNOWN ·Phase: PHASE2
-
Neoadjuvant and Adjuvant Anti-PD1 or Combinations for Locoregionally Advanced Melanoma
NCT06295159 ·Status: RECRUITING ·Phase: PHASE2
-
Molecularly Targeted Therapy in Treating Patients With BRAF Wild-type Melanoma That is Metastatic
NCT02094872 ·Status: COMPLETED ·Phase: PHASE2
-
Predictive Clinical Features for Response to Adjuvant Immunotherapy in Stage II,III and IV Resected Melanoma
NCT05527795 ·Status: RECRUITING
-
Study of PI-88 in Patients With Advanced Melanoma
NCT00068172 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of Investigational Treatments in Combination With Standard of Care Immune Checkpoint Inhibitors in Participants With Advanced Melanoma
NCT02723006 ·Status: TERMINATED ·Phase: PHASE1
-
Neoadjuvant and Adjuvant Checkpoint Blockade
NCT02519322 ·Status: COMPLETED ·Phase: PHASE2
-
Symptoms of Immune Checkpoint Inhibitor Therapy in Cutaneous Melanoma
NCT07148245 ·Status: RECRUITING
-
A Study of Adjuvant Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab for Resected High-Risk Melanoma in Participants With High-Risk Stage II-IV Melanoma (MK-7684A-010/KEYVIBE-010)
NCT05665595 ·Status: COMPLETED ·Phase: PHASE3
-
A Phase 1b Study of Atezolizumab in Combination With Vemurafenib or Vemurafenib Plus Cobimetinib in Participants With BRAFV600-Mutation Positive Metastatic Melanoma
NCT01656642 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase II Study of Neoadjuvant Pembrolizumab & Lenvatinib for Resectable Stage III Melanoma
NCT04207086 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Patient-led Surveillance Compared to Clinician-led Surveillance in People Treated for Localised Melanoma.
NCT03581188 ·Status: COMPLETED ·Phase: NA
-
Pembrolizumab and Ibrutinib in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery
NCT03021460 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Anti-PD 1 Brain Collaboration for Patients With Melanoma Brain Metastases
NCT02374242 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Relative Bioavailability Study of Subcutaneous Injection Versus Intravenous Infusion of Pembrolizumab (MK-3475) in Participants With Advanced Melanoma (MK-3475-555/KEYNOTE-555)
NCT03665597 ·Status: COMPLETED ·Phase: PHASE1
-
TNF-Inhibitor as Immune Checkpoint Inhibitor for Advanced MELanoma
NCT03293784 ·Status: COMPLETED ·Phase: PHASE1
-
An Observational Study of Adjuvant (Post-surgery) Therapy With Nivolumab for Resected (Completely Removed) Melanoma in Australia
NCT04146324 ·Status: COMPLETED
-
A Study is to Understand the Treatment Patterns for Immunotherapy Agents and BRAF/MEK Inhibitors Used in the Treatment of Advanced Melanoma
NCT03696069 ·Status: COMPLETED
-
Neoadjuvant Ipilimumab/Nivolumab for Patients With Recurrent, High Risk, Resectable Melanoma
NCT06365619 ·Status: RECRUITING ·Phase: PHASE2