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Investigating Changes in Responses to Controlled Effective Doses of Ozone at Different Exercise Intensities

NCT06513754 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2025-03-30

No results posted yet for this study

Summary

The project will look to investigate whether exercise during ozone exposure performed for a shorter duration at a higher intensity is more harmful than exercise performed for a longer duration at a lighter intensity. To assess this, participants will perform these exercise conditions with and without ozone exposure and researchers will assess changes in lung function, subjective symptoms, and breathing mechanics to determine which is more harmful.

Conditions

  • Ozone
  • Exercise Intensity

Interventions

OTHER

Ozone

Ozone is a pollutant that forms as a result of nitrogen oxides or volatile organic compounds interacting with UV radiation. Ozone will be created via a generator in the lab

BEHAVIORAL

Heavy Intensity

Heavy intensity exercise between the first and second ventilatory threshold for 45 minutes

BEHAVIORAL

Moderate Intensity

Moderate intensity exercise below the first ventilatory threshold for approximately 75 minutes

OTHER

Filtered Air

Exposure to filtered air (\<10 ppb ozone)

Sponsors & Collaborators

  • Natural Sciences and Engineering Research Council, Canada

    collaborator OTHER

  • Michael Koehle

    lead OTHER

Principal Investigators

  • Michael Koehle, MD, PhD · University of British Columbia

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-09-30
Primary Completion
2025-04-30
Completion
2025-08-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06513754 on ClinicalTrials.gov