MedTrace Logo

Volume Kinetics of Fluid Resuscitation in Early Sepsis

NCT06499701 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 15

Last updated 2026-03-18

No results posted yet for this study

Summary

The recommended volume resuscitation for patients with early sepsis-induced hypoperfusion is at least 30 ml/kg of crystalloid administered within the first three hours. However, this standardized approach does not account for individual patient variability and lacks personalization. Additionally, the effects of administering 30 ml/kg on intercompartmental fluid shifts between the plasma and interstitial compartments remain unclear. This study aims to describe the volume kinetics of administering 30 ml/kg of Ringer's Lactate in patients with early sepsis-induced hypoperfusion within the first three hours.

Conditions

  • Fluid and Electrolyte Imbalance

Interventions

DRUG

Ringer's Lactate

Ringer's Lactate is administered at a dose of 30ml/kg, with the first 20ml/kg given at a constant rate over the initial 30 minutes, followed by a 30-minute pause, and then an additional 10ml/kg over the next 15 minutes, completing the infusion within 75 minutes.

Sponsors & Collaborators

  • Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu

    lead OTHER

Principal Investigators

  • Robert Hahn, Professor · Karolinska Institutet: Stockholm, SE (Department of Clinical Sciences, Danderyd Hospital) Employment

  • Serban-Ion Bubenek-Turconi, Professor · "Prof CC Iliescu" Emergency Institue for Cardiovascular Diseases

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-06-19
Primary Completion
2026-07-01
Completion
2026-07-30
FDA Drug
Yes

Countries

  • Romania

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06499701 on ClinicalTrials.gov