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Effect of High Versus Low Fraction of Inspired Oxygen During Alveolar Recruitment

NCT06494410 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2024-07-15

No results posted yet for this study

Summary

Intraoperative absorption atelectasis is associated with decreased lung compliance, impaired oxygenation, increased pulmonary vascular resistance, and lung injury.

The alveolar recruitment maneuver (RM) with positive-end expiratory pressure (PEEP) has been advocated as efficient for absorption atelectasis treatment.

During general anesthesia, absorption atelectasis reportedly occurs in most patients especially during laparoscopic surgery, the increased abdominal pressure of capnoperitoneum may shift the diaphragm cranially and decrease respiratory compliance

Conditions

  • Bariatric Surgery Candidate
  • Atelectasis

Interventions

PROCEDURE

High versus Low Fraction of Inspired Oxygen

to compare the effect of high oxygen fraction (FiO2 1.0) vs. low oxygen fraction (FiO2 0.4) on clinical outcome on intraoperative and postoperative atelectasis and PPC. We will asses the impact of FiO2, especially during RM, on atelectasis development, using modified LUSS in obese patients with atelectasis undergoing laparoscopic bariatric surgery.

Sponsors & Collaborators

  • Ain Shams University

    collaborator OTHER

  • Egymedicalpedia

    lead INDUSTRY

Principal Investigators

  • Madiha Metwaly Zidan, Professor · Department of Anesthesia and I.C.U. faculty of Medicine,Ain Shams university, Egypt

  • Ahmed Ali Fawaz, Professor · Department of Anesthesia and I.C.U. faculty of Medicine,Ain Shams university, Egypt

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-07
Primary Completion
2024-07-07
Completion
2024-07-10

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06494410 on ClinicalTrials.gov