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The Innate Immune Response and Enteric Nervous System in Crohn's Disease.

NCT06485193 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 12

Last updated 2024-07-03

No results posted yet for this study

Summary

The study aims to explore the relationships between inflammation, nerve changes, and the expression of interferon-stimulated proteins in inflamed and non-inflamed bowel areas from patients with Crohn's disease. Crohn's disease is a chronic inflammatory condition with complex causes and mechanisms that remain uncertain despite extensive research.

Methods and Procedures This exploratory study utilizes tissue samples from a clinical biobank at Aalborg University Hospital. The samples are paraffin-embedded blocks from which tissue sections are prepared for immunohistochemical and histological staining. The study focuses on assessing the expression of interferon-stimulated proteins through optimized immunohistochemical staining methods, ensuring reproducibility via automated machines. The protein expressions are then analyzed qualitatively and semi-quantitatively and compared with structural changes in the bowel tissues.

Conditions

  • Crohn Disease

Interventions

DIAGNOSTIC_TEST

Immunohistochemistry

Immunohistochemical analysis of archived diagnostic tissue samples.

Sponsors & Collaborators

  • Aalborg University Hospital

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-04
Primary Completion
2024-06-01
Completion
2024-06-01

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06485193 on ClinicalTrials.gov