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Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease

NCT04088773 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 232

Last updated 2025-06-13

No results posted yet for this study

Summary

This research study will evaluate if specific blood, stool and MRI tests can tell the difference between bowel wall inflammation without scarring and bowel wall inflammation with scarring that can cause bowel blockages requiring surgery.

Conditions

  • Crohn Disease

Interventions

DIAGNOSTIC_TEST

blood biomarkers

biomarkers to distinguish fibrotic vs non-fibrotic CD lesions

DIAGNOSTIC_TEST

stool biomarkers

fecal biomarkers of inflammation, mucosal inflammation

DIAGNOSTIC_TEST

MRI imaging

MRI imaging to detect bowel wall fibrosis and to detect inflamed, non-fibrotic from inflamed, fibrotic bowel

Sponsors & Collaborators

  • The Leona M. and Harry B. Helmsley Charitable Trust

    collaborator OTHER

  • Children's Hospital Medical Center, Cincinnati

    lead OTHER

Principal Investigators

  • Jonathan Dillman, MD, MSc · Children's Hospital Medical Center, Cincinnati

Eligibility

Min Age
8 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-11-01
Primary Completion
2023-09-01
Completion
2026-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04088773 on ClinicalTrials.gov