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Improving Vaccine Acceptance Through EHR Integrated Patient- and Provider-Facing Decision Support

NCT06482450 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1200

Last updated 2026-05-14

No results posted yet for this study

Summary

The goal of this project is to establish the technical feasibility of a scalable, integrated platform to improve patient informed decision-making and increase vaccine uptake and to evaluate the effectiveness of the integrated platform to improve vaccine uptake.

Conditions

  • Vaccine Hesitancy
  • Vaccine Refusal

Interventions

OTHER

LetsTalkShots (patient-facing CDS)

LetsTalkShots is a website which provides patients/parents with tailored videos addressing vaccine concerns.

OTHER

LetsTalkShots (provider-facing CDS)

The provider-facing CDS component will propagate patient concerns obtained from LetsTalkShots (and the appropriate talking points to address the talking points) into the electronic health record (EHR) for the provider at the point of care.

OTHER

Appointment Reminder Message

The regular text message and e-mail appointment reminder includes a vaccine primer (e.g. "Vaccines are due and reserved for the participant's child"), but no patient- or provider-facing CDS.

Sponsors & Collaborators

  • Children's Healthcare of Atlanta

    collaborator OTHER

  • Emory University

    collaborator OTHER

  • Merck Sharp & Dohme LLC

    collaborator INDUSTRY

  • Johns Hopkins Bloomberg School of Public Health

    lead OTHER

Principal Investigators

  • Daniel Salmon, PhD · Johns Hopkins Bloomberg School of Public Health

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-06-11
Primary Completion
2026-05-11
Completion
2026-07-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06482450 on ClinicalTrials.gov