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Effects of Drugs on Stress Memories

NCT06471647 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2025-08-07

No results posted yet for this study

Summary

There is evidence that cannabinoids, including delta-9-tetrahydrocannabinol (THC), reduce responses to acute stress and fear-related stimuli, but few studies have examined the effects of THC on memories of stressful experiences. The researchers hypothesize that THC will attenuate behavioral and physiological responses to negative valence stimuli, including memories of aversive experiences.

Conditions

  • Delta-9-tetrahydrocannabinol (THC)
  • Stress

Interventions

DRUG

delta-9-tetrahydrocannabinol (THC) (5)

5 mg of THC

DRUG

Placebo

Placebo - dextrose

DRUG

delta-9-tetrahydrocannabinol (THC) (10)

10 mg of THC

Sponsors & Collaborators

  • University of Chicago

    lead OTHER

Principal Investigators

  • Harriet de Wit · University of Chicago

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-07-01
Primary Completion
2025-03-25
Completion
2025-03-25
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06471647 on ClinicalTrials.gov