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Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators

NCT03152175 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 64

Last updated 2021-06-18

No results posted yet for this study

Summary

Police officers, correctional service officers, and 911-operators are at increased risk for suffering from trauma-related disorders due to their direct and indirect exposure to life-threatening events, such as shootings, violent assaults, or car accidents, among others. Typical treatments for post-traumatic stress disorders include psychotherapy and pharmacological therapies (i.e., antidepressants). Although these interventions are effective for many sufferers, they all have limitations. Thus, the investigators propose to explore the usefulness of a new therapeutic technique, reconsolidation blockade, which involves reactivating the trauma memory while under the influence of propranolol. Objectives and hypotheses: To explore the efficacy and cost-effectiveness of reconsolidation blockade therapy as an adjunct treatment for trauma- and stressor-related disorders as defined in the Diagnostic and Statistical Manual Mental Disorders-5. The investigators hypothesize that, compared to the control group, 5 weekly trauma-memory reactivations under propranolol treatment will confer a significant reduction in trauma-related symptoms and significantly more health-related economic benefits. Stress symptoms and health-related costs will be assessed at 7, 26 and 52 weeks after study inclusion. In this study, the investigators will also explore the effects of reconsolidation blockade with propranolol on various neuropsychological functions.

Conditions

  • Trauma and Stressor Related Disorders
  • Post-traumatic Stress Disorders
  • Adjustment Disorders
  • Acute Stress Disorder

Interventions

DRUG

Propranolol Hydrochloride

1mg / kg of propranolol hydrochloride, oral capsule

DRUG

Placebo

1mg / kg of matched placebo, oral capsule

Sponsors & Collaborators

  • Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail

    collaborator OTHER

  • Douglas Mental Health University Institute

    lead OTHER

Principal Investigators

  • Alain Brunet, PhD. · Douglas Mental Health University Institute

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-03-30
Primary Completion
2022-03-31
Completion
2023-03-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03152175 on ClinicalTrials.gov