Dobutamine for Management of Surgical Patients With Septic Shock

Summary

Septic shock is the last and most severe stage of sepsis and is defined by extremely low blood pressure, despite lots of intravenous fluids. The incidence of septic shock related cardiomyopathy was 10% to 70%. Besides, general anesthesia will inhibit the sympathetic nervous system, reduce myocardial contractility and aggravate cardiac dysfunction. No randomized controlled trials have yet explore the effects of dobutamine on clinical outcomes for patients with septic shock undergoing surgery under general anesthesia.

Conditions

• Patients With Septic Shock
• Surgical Patients
• General Anesthesia

Interventions

DRUG

Dobutamine

Patients with septic shock in Dobutamine group will be initiated on Dobutamine at 5 mcg/kg/min when electrocardiogram, invasive blood pressure, and oxygen saturation were monitored.

DRUG

Norepinephrine

Norepinephrine was titrated to maintain a mean arterial pressure at 65mmHg or more in both groups.

Sponsors & Collaborators

• Ningbo No. 1 Hospital

  collaborator OTHER

• Lishui Country People's Hospital

  collaborator OTHER

• The Central Hospital of Lishui City

  collaborator OTHER

• Zhejiang Provincial Tongde Hospital

  collaborator OTHER

• Ningbo No.2 Hospital

  collaborator OTHER

• Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University

  collaborator OTHER

• The First Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Zunyi Medical College

  collaborator OTHER

• The Second Hospital of Hebei Medical University

  collaborator OTHER

• Affiliated Hospital of Jiaxing University

  collaborator OTHER

• First Affiliated Hospital of Xinjiang Medical University

  collaborator OTHER

• The First Affiliated Hospital of Anhui Medical University

  collaborator OTHER

• Huaibei Peolple's Hospital

  collaborator UNKNOWN

• Anqing People's Hospital of Anhui Medical University

  collaborator UNKNOWN

• The Second Hospital University of South China

  collaborator OTHER

• The First Affiliated Hospital of University of South China

  collaborator OTHER

• Wenzhou people's hospital，zhejiang province,China

  collaborator UNKNOWN

• People's Hospital of Xinjiang Uygur Autonomous Region

  collaborator OTHER

• The First Clinical College of Harbin University

  collaborator UNKNOWN

• The First Affiliated Hospital of Shihezi University Medical College

  collaborator UNKNOWN

• Weifang People's Hospital

  collaborator OTHER

• Tianjin Medical University General Hospital

  collaborator OTHER

• Central Hospital of Heng Yang

  collaborator UNKNOWN

• First Affiliated Hospital of Shenzhen University

  collaborator UNKNOWN

• Henan Provincial People's Hospital

  collaborator OTHER

• Southwest Hospital, China

  collaborator OTHER

• The First People's Hospital of Zunyi

  collaborator OTHER

• Affiliated Hospital of Guangdong Medical University

  collaborator OTHER

• Union hospital of Fujian Medical University

  collaborator OTHER

• Bijie Hospital of Zhejiang Provincial People's Hospital

  collaborator UNKNOWN

• Red Cross Hospital, Hangzhou, China

  collaborator OTHER

• Weihai Municipal Hospital

  collaborator OTHER

• The First Affiliated Hospital of Soochow University

  collaborator OTHER

• Zhejiang Cancer Hospital

  collaborator OTHER

• Renmin Hospital of Wuhan University

  collaborator OTHER

• Wuhan Third Hospital

  collaborator OTHER

• Tongji Hospital

  collaborator OTHER

• Zhujiang Hospital

  collaborator OTHER

• Fuyang Hospital of Anhui Medical University

  collaborator UNKNOWN

• The Hospital of Suixi County

  collaborator UNKNOWN

• Fujian Provincial Hospital

  collaborator OTHER

• Guizhou Provincial People's Hospital

  collaborator OTHER

• Zhejiang Provincial People's Hospital

  collaborator OTHER

• First Affiliated Hospital of Zhejiang University

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-06-18

Primary Completion

2025-11-15

Completion

2025-11-15

Countries

• China

Study Locations