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Metabolic Dysregulation as Biomarker of Frailty: Role of the Mitochondrial Dysfunction

NCT06433427 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 75

Last updated 2024-05-29

No results posted yet for this study

Summary

The goal of this observational study is to evaluate the presence of mitochondrial dysfunction related to oxidative stress and its possible role in frailty, with and without multimorbidity, and to identify possible frailty biomarkers correlated with mitochondrial dysfunction. The main questions it aims to answer are:

* What is the role of oxidative stress-related mitochondrial dysfunction in frailty, taking into account the interaction with multimorbidity.
* What could be the specific biomarkers associated with mitochondrial dysfunction in the assessment of frailty.

In order to reach the study goals, we will enroll three categories of older adults:

* Non-Frail without Multimorbidity (NFWoM);
* Frail with Multimorbidity (FWM);
* Frail without Multimorbidity (FWoM).

Each individual will undergo an assessment of frailty phenotype and multimorbidity, and the collection of blood samples to isolate Peripheral Blood Mononuclear Cells (PBMCs). The identification of frailty biomarkers in each group of participants will be performed by combining untargeted metabolomics-based approaches and functional studies on specific mitochondrial dysfunctions performed on PBMCs and their subpopulations. Multivariate statistical and machine learning techniques will characterize the three clinical phenotype groups based on molecular data.

Conditions

Sponsors & Collaborators

  • University of Milano Bicocca

    collaborator OTHER

  • University Hospital of Ferrara

    lead OTHER

Principal Investigators

  • Caterina Trevisan, PhD · Università degli Studi di Ferrara

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-05-29
Primary Completion
2025-05-30
Completion
2026-02-22

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06433427 on ClinicalTrials.gov