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Effect of Infections and Global DNA Methylation on Frailty Trajectories in Hospitalized Older Patients (INFRAGEN)

NCT06430073 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 340

Last updated 2024-05-28

No results posted yet for this study

Summary

This prospective multicenter study aims at exploring the impact of infections on intra-hospital and 3-month changes in the frailty profile of older inpatients.

To understand the complex pathways under the relationship between infections and frailty, this study will evaluate infection-related clinical and biochemical markers of systemic inflammation and genetics/epigenetics markers at ward admission.

The interplay between clinical, functional, and genetics/epigenetics factors will be evaluated in a subgroup of patients by testing whether 3-month changes in frailty concur with changes in the genomic DNA markers. This study will help characterize the pathophysiological mechanisms of frailty and identify at-risk conditions that may accelerate its course.

Conditions

Sponsors & Collaborators

  • Azienda Ospedaliera di Padova

    collaborator OTHER

  • Fondazione IRCCS San Gerardo dei Tintori

    collaborator OTHER

  • Azienda Ospedaliera Universitaria Policlinico

    collaborator OTHER

  • University Hospital of Ferrara

    lead OTHER

Principal Investigators

  • Stefano Volpato, MD · Università degli Studi di Ferrara

Eligibility

Min Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-05-20
Primary Completion
2025-09-01
Completion
2026-03-01

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06430073 on ClinicalTrials.gov