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Tranexamic Acid for Reduction of Transfusion in Abdominal Surgery

NCT06414031 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 850

Last updated 2026-04-29

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if the administration of tranexamic acid can reduce the necessity of blood transfusions in adult patients undergoing major abdominal surgery. . It will also inform about safety of tranexamic acid in this setting.

The main question it aims to answer is: Does tranexamic acid lower the probability of receiving at least one blood transfusion during or after surgery?

Participants will compare tranexamic acid o a placebo (a look-alike substance that contains no drug) to see if tranexamic acid works to reduce the necessity of a blood transfusion.

Conditions

  • Surgical Blood Loss
  • Transfusion-dependent Anemia
  • Abdomen Disease

Interventions

DRUG

Tranexamic Acid

Intravenous administration

DRUG

Placebo

Intravenous administration

Sponsors & Collaborators

  • German Federal Ministry of Education and Research

    collaborator OTHER_GOV

  • Coordinating Centre for Clinical Trials Halle

    collaborator UNKNOWN

  • Ulrich Ronellenfitsch, MD

    lead OTHER

Principal Investigators

  • Ulrich Ronellenfitsch, MD · Medical Faculty of the Martin Luther University Halle-Wittenberg

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-06-17
Primary Completion
2026-11-30
Completion
2026-11-30

Countries

  • Germany

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06414031 on ClinicalTrials.gov