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Comparison of Aprotinin and Tranexamic Acid in Routine Cardiac Surgery

NCT00396760 · Status: UNKNOWN · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 220

Last updated 2006-11-07

No results posted yet for this study

Summary

The hypothesis of this study is that the antifibrinolytic drugs aprotinin and tranexamic acid equally influence bleeding tendency and transfusion requirement in patients undergoing first time cardiac procedures with a low risk of increased postoperative bleeding.Only patients undergoing first time CABG or first time aortic valve replacement are included in this study.

Conditions

  • Bleeding and Cardiac Surgery
  • Allogeneic Blood Transfusion
  • Aortic Valve Replacement
  • Coronary Artery Bypass Graft Surgery

Interventions

DRUG

aprotinin or tranexamic acid

Sponsors & Collaborators

  • German Heart Center

    lead OTHER

Principal Investigators

  • Wulf Dietrich, MD, PhD · Department of Anesthesiology, German Heart Center Munich

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-01-31
Completion
2006-07-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00396760 on ClinicalTrials.gov