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Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin

NCT06405646 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 102

Last updated 2026-03-06

No results posted yet for this study

Summary

The main aim of the presented project will be to examine the concentration of selected receptors (CB1, CB2, TRPV-1) showing affinity for binding to cannabidol (CBD) and cannabinol (CBN) in blood samples collected from people with chronic pain in the masticatory muscles and from people without this pain. Moreover, study participants will be examined by a qualified doctor, according to the validated and standardized international DC/TMD protocol (Diagnostic Criteria for Temporomandibular Disorders) and the criteria included in ICOP-1 (International Classification of Orofacial Pain, 1st edition). The nature and duration of pain, psychoemotional state and central sensitization (the phenomenon of increased reactivity of the nervous system to stimuli) will be determined using validated questionnaires. The obtained results will be subjected to statistical analysis in order to check the relationships between the examined parameters.

Conditions

  • Myalgia
  • Muscle Pain
  • Orofacial Pain
  • Headache, Tension
  • Headaches Muscular

Interventions

DIAGNOSTIC_TEST

Blood CB1, CB2, TRPV-1 concentration measurement

In each of the patients blood CB1, CB2, TRPV-1 concentration will be measure

Sponsors & Collaborators

  • Wroclaw Medical University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-04-01
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06405646 on ClinicalTrials.gov