Endovascular Treatment for eXtra-Large Ischemic Stroke

Summary

The role of endovascular thrombectomy in patients with extra-large ischemic burden is still unclear. The XL STROKE-2 randomized trial is aiming to investigate the efficacy and safety of mechanical thrombectomy in acute extra-large ischemic stroke patients with large vessel occlusion.

Conditions

• Stroke, Acute Ischemic

Interventions

DRUG

Medical management

Medical management includes IV thrombolysis, antiplatelet, and/or anticoagulation.

PROCEDURE

Endovascular thrombectomy

Endovascular thrombectomy with stent-retriever, local aspiration, angioplasty, and/or stenting.

Sponsors & Collaborators

• The First Affiliated Hospital, University of South China

  collaborator UNKNOWN

• Xiangtan Central Hospital

  collaborator OTHER

• Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University

  collaborator UNKNOWN

• Longyan First Affiliated Hospital of Fujian Medical University

  collaborator UNKNOWN

• Taizhou First People's Hospital

  collaborator OTHER

• Zhangzhou Affiliated Hospital of Fujian Medical University

  collaborator OTHER

• Zhongming Qiu

  lead OTHER

Principal Investigators

• Guangxiong Yuan · Xiangtan Central Hospital

• Congguo Yin · Hangzhou First Hospital of Zhejiang University

• Tingyu Yi · Zhangzhou Affiliated Hospital of Fujian Medical University

• Chong Zheng · Longyan First Hospital of Fujian Medical University

• Chenghua Xu · Taizhou First People's Hospital

• Zhongfan Ruan · The First Affiliated Hospital, Hengyang Medical School, University of South China

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-06-16

Primary Completion

2026-10-31

Completion

2027-01-31

Countries

• China

Study Locations