CHinese Acute Tissue-Based Imaging Selection for Lysis In Stroke -Tenecteplase

Summary

To select the best dosage of tenecteplase for acute ischemic stroke patients (onset time 4.5-24h) of large vessel occlusion using early combined CT/MR imaging outcomes

Conditions

• Stroke

Interventions

DRUG

Low dose tenecteplase

Intravenous (IV) tenecteplase 0.25 mg/kg (single bolus; maximum dose 25 mg)

DRUG

High dose tenecteplase

Intravenous (IV) tenecteplase 0.32 mg/kg (single bolus; maximum dose 32 mg)

Sponsors & Collaborators

• The First Affiliated Hospital of Shanxi Medical University

  collaborator OTHER

• Ningbo No. 1 Hospital

  collaborator OTHER

• Zhejiang Province People's Hospital

  collaborator UNKNOWN

• Shanghai 5th People's Hospital

  collaborator OTHER

• Shanghai 10th People's Hospital

  collaborator OTHER

• Shanghai 6th People's Hospital

  collaborator OTHER

• The Second Affiliated Hospital of Chongqing Medical University

  collaborator OTHER

• The Second People's Hospital of Huai'an

  collaborator OTHER

• Pu'er City People's Hospital

  collaborator UNKNOWN

• ShuGuang Hospital

  collaborator OTHER

• Shanghai East Hospital

  collaborator OTHER

• First People's Hospital of Shenyang

  collaborator OTHER

• Huashan Hospital

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-12-09

Primary Completion

2021-12-31

Completion

2021-12-31

Countries

• China

Study Locations