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Intravenous Tirofiban Versus Alteplase Before Mechanical Thrombectomy in Stroke

NCT05728333 · Status: RECRUITING · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 800

Last updated 2025-12-26

No results posted yet for this study

Summary

In patients with acute ischemic stroke secondary to large vessel occlusion, the role of intravenous adjunctive medications, such as tirofiban, or alteplase before endovascular thrombectomy has not been well investigated. This trial aim to evaluate the efficacy and safety of intravenous tirofiban versus alteplase for acute ischemic stroke patients with large vessel occlusion piror to endovascular thrombectomy.

Conditions

  • Stroke, Acute Ischemic

Interventions

DRUG

Tirofiban

Intravenous tirofiban before endovascular thrombectomy.

DRUG

Alteplase

Intravenous alteplase before endovascular thrombectomy.

Sponsors & Collaborators

  • Zhejiang University

    collaborator OTHER

  • Xinqiao Hospital of Chongqing

    lead OTHER

Principal Investigators

  • Congguo Yin, Doctor · Hangzhou First Hospital of Zhejiang University

  • Zhongming Qiu, Doctor · The 903rd Hospital of PLA, China

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-11-28
Primary Completion
2026-02-28
Completion
2026-07-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05728333 on ClinicalTrials.gov