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The PRO-FUTURE Project

NCT06382233 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 85

Last updated 2024-04-30

No results posted yet for this study

Summary

The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls. The main question it aims to answer are:

* Are Urinary single-cell and extracellular vesicles (EVs) screening useful to stage the intrarenal injury and repair processes in UPJO babies?
* Do babies with unilateral UPJO have a whole blood gene expression profiling (WBGEP) allowing an accurate unilateral UPJO diagnosis?

Conditions

  • Ureteropelvic Junction Obstruction
  • Chronic Kidney Diseases

Interventions

DIAGNOSTIC_TEST

Identification of Diagnostic Biomarkers

Urinary single-cell and EVs screening to stage the intrarenal injury and repair processes in UPJO babies and identification of the whole blood gene expression profiling of babies with unilateral UPJO. Data deriving from patients with unilateral UPJO will be compared with data deriving from controls.

Sponsors & Collaborators

  • University of Milan

    collaborator OTHER

  • A.O.R.N. Santobono-Pausilipon

    collaborator UNKNOWN

  • University of Modena and Reggio Emilia

    collaborator OTHER

  • Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

    collaborator OTHER

  • University of Campania Luigi Vanvitelli

    lead OTHER

Eligibility

Min Age
1 Day
Max Age
5 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-30
Primary Completion
2026-01-30
Completion
2028-01-30

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06382233 on ClinicalTrials.gov