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Pediatric Eosinophilic Esophagitis (pedEoE): Effect of Allergen Heat Denaturation on EoE Remission: a Pilot Trial

NCT06381219 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2026-05-05

No results posted yet for this study

Summary

The objective of the study is to study whether the introduction of heated food products (more specifically heated hen's egg and/or cow's milk) in children with EoE would be possible without re-occurrence of the eosinophilic inflammation, while the intake of less heated products might cause disease recidive. Moreover, we would like to study whether the gradual re-introduction of less heated products after the most heated form is tolerated, could lead to tolerance induction in EoE.

Conditions

  • Eosinophilic Esophagitis

Interventions

OTHER

Implementation of cow's milk in decreasingly heated forms

Implementation of cow's milk in decreasingly heated forms to assess maintained remission of EoE

OTHER

Implementation of hen's egg in decreasingly heated forms

Implementation of hen's egg in decreasingly heated forms to assess maintained remission of EoE

Sponsors & Collaborators

  • Universitaire Ziekenhuizen KU Leuven

    lead OTHER

Principal Investigators

  • Ilse Hoffman, Prof. Dr. · Co-investigator, pediatric gastro-enterology

  • Gert De Hertogh, Prof. Dr. · Co-investigator, pathological anatomy

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
12 Months
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-12-19
Primary Completion
2027-12-31
Completion
2028-12-31

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06381219 on ClinicalTrials.gov