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Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS

NCT06367218 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 480

Last updated 2025-01-03

No results posted yet for this study

Summary

Non-tracheal intubated combined anesthesia with preserved spontaneous breathing significantly enhances the quality and speed of recovery post-VATS for patients undergoing lung nodule surgery. The "opioid-sparing strategy," which substitutes ketamine for opioids during surgery, not only provides effective analgesia but also protects perioperative lung function and reasonably prevents the occurrence of opioid-related adverse reactions; it also reduces medical costs and shortens the average hospital stay. However, the degree of benefit to patients lacks high-level clinical evidence. This study aims to comprehensively assess the effect of opioid-free combined anesthesia with preserved spontaneous breathing for VATS lung nodule surgery on postoperative rapid recovery from multiple aspects including postoperative lung function and pulmonary complications, pain, gastrointestinal function, nausea/vomiting, cognitive function, and depression/anxiety, intending to expand the dataset and application prospects in this field, and increase feasibility experience.

Conditions

  • Video-assisted Thoracoscopic Lung Surgery；Anesthesia

Interventions

DRUG

opioid based strategy

Induction and maintenance of anesthesia with opioids

DRUG

opioid-free strategy

Esketamine was used for induction and maintenance of anesthesia

PROCEDURE

Laryngeal mask airway; Preserved spontaneous breathing

The patient used a laryngeal mask to maintain spontaneous breathing

PROCEDURE

Double lumen tracheal tube; Mechanical ventilation

The patient was mechanically ventilated using a double-lumen tracheal catheter

Sponsors & Collaborators

  • Tongji Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-10-01
Primary Completion
2026-07-01
Completion
2026-08-01

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06367218 on ClinicalTrials.gov