Study of the Depth of Anesthesia on Postoperative Clinical Outcome in Patients With Supratentorial Tumor

Summary

Recent studies have shown that deep anesthesia is associated with poor outcome. There is still lack of randomized controlled trials with large sample size on the effect of depth of anesthesia on the postoperative outcomes in patients undergoing brain tumor resection. The investigators are performing a randomized and parallel group trial. The aim of the study is to determine whether there is a causal relationship between the depth of anesthesia and postoperative clinical outcome in patients undergoing supratentorial tumor surgery.

Conditions

• Anesthesia, Brain Tumor, Supratentorial,Outcome

Interventions

OTHER

Bispectral index will be targeted at 50

The depth of general anesthesia will be monitored by bispectral index (BIS) at 50.

OTHER

Bispectral index will be targeted at 35

The depth of general anesthesia will be monitored by bispectral index (BIS) at 35.

Sponsors & Collaborators

• Shanxi Provincial People's Hospital

  collaborator OTHER_GOV

• Guiyang Jinyang Hospital

  collaborator UNKNOWN

• Beijing Sanbo Brain Hospital

  collaborator OTHER

• The Second Hospital of Hebei Medical University

  collaborator OTHER

• The Affiliated Hospital of Inner Mongolia Medical University

  collaborator OTHER

• Chinese PLA General Hospital

  collaborator OTHER

• Anhui Provincial Hospital

  collaborator OTHER_GOV

• Guangdong 999 Brain Hospital

  collaborator OTHER

• Zhejiang University

  collaborator OTHER

• Beijing Tiantan Hospital

  lead OTHER

Principal Investigators

• Ruquan Han, M.D., Ph.D · Department of Anesthesiology, Beijing Tian Tan Hospital

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-02-01

Primary Completion

2019-11-04

Completion

2019-11-04

Countries

• China

Study Locations