MedTrace Logo

Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy

NCT06360289 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 346

Last updated 2026-05-20

No results posted yet for this study

Summary

This is a single-center observational study evaluating the potential value of NfL as a biomarker for diagnosis, detection of disease onset, monitoring of disease progression, and treatment response in asymptomatic carriers of TTR variants and symptomatic hATTR amyloidosis patients with polyneuropathy.

Conditions

  • Hereditary Amyloidosis, Transthyretin-Related
  • Asymptomatic Carrier State

Interventions

OTHER

Standard of Care

This is an observational study. No study drug will be administered as a part of the study, participants will be treated according to the decision of the treating physician.

Sponsors & Collaborators

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-04-25
Primary Completion
2027-12-01
Completion
2027-12-01

Countries

  • France

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06360289 on ClinicalTrials.gov