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Early Onset Colorectal Cancer Detection

NCT06342401 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2026-01-28

No results posted yet for this study

Summary

Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagnosed CRC cases and it stands as the first cause of cancer-related death in young men and the second for young women.

This study aims to detect EOCRC with a non-invasive test, using a blood-based molecular assay based on microRNA (ribonucleic acid)

Conditions

  • Colorectal Cancer
  • Colorectal Neoplasms
  • Colorectal Adenocarcinoma
  • Colorectal Cancer Stage I
  • Colorectal Cancer Stage IV
  • Colorectal Cancer Stage II
  • Colorectal Cancer Stage III
  • Colorectal Neoplasms Malignant

Interventions

DIAGNOSTIC_TEST

ENCODE

A panel of microRNA, both cell-free and exosomes, whose expression level is tested from plasma samples from patients with early onset colorectal cancer and non-disease controls.

Sponsors & Collaborators

  • City of Hope Medical Center

    lead OTHER

Principal Investigators

  • Ajay Goel, PhD · City of Hope Medical Center

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-04-15
Primary Completion
2026-06-18
Completion
2026-06-18

Countries

  • United States
  • Italy
  • Japan
  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06342401 on ClinicalTrials.gov