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Potential Role of Sirtuins As Epigenetic Biomarkers of the Patient with Atherosclerosis or Calcific Aortic Stenosis

NCT06337227 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 3

Last updated 2025-03-11

No results posted yet for this study

Summary

The project aims to shed light on the role of Sirtuins, enzymes belonging to the third class of histone deacetylases (class III) involved in epigenetic modifications (deacetylation), focusing mainly on Sirtuin 6 (SIRT6), as a regulator of atherosclerosis and severe aortic valve stenosis through molecular-based and epigenetic studies in human VSMC cells.

Conditions

  • Atherosclerosis and Calcific Aortic Stenosis with and Without Diabetes

Interventions

DIAGNOSTIC_TEST

lncRNA signature analyses

Specific validation experiments will be performed by Real-Time PCR (C-reactive protein), Western Blot, flow cytometry and microscopy

Sponsors & Collaborators

  • Federico II University

    collaborator OTHER

  • IRCCS SYNLAB SDN

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-19
Primary Completion
2025-10-31
Completion
2026-10-31

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06337227 on ClinicalTrials.gov