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Tau Biomarkers in Late-onset Psychosis (LOP)

NCT06336382 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 16

Last updated 2025-09-29

No results posted yet for this study

Summary

Hallucinations or delusions that occur for the first time in older people with no acute medical problems or mood symptoms may be related to impending dementia. This study aims to confirm this hypothesis using novel blood biomarkers and Positron Emission Tomography (PET) imaging tracers, as well as non-invasive testing.

Conditions

  • Late Onset Schizophrenia
  • Delusional Disorder (Late Onset)

Interventions

DIAGNOSTIC_TEST

Tau PET imaging scan

Subjects will be scanned with novel tau PET tracer \[18F\] PI-2620 to determine whether neurofibrillary tangle pathology is present.

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • Jeremy Koppel

    lead OTHER

Principal Investigators

  • Jeremy Koppel, MD · Northwell Health

Eligibility

Min Age
65 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-02-16
Primary Completion
2026-12-31
Completion
2027-06-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06336382 on ClinicalTrials.gov