Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models
NCT06326853 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 200
Last updated 2024-06-11
Summary
The goal of this observational study is to evaluate, retrospectively and prospectively, the effect of different hormonal and neuropeptide dysfunctions on the body composition of patients suffering from hypothalamic-pituitary pathologies, and to evaluate the potential beneficial effect of surgical and medical treatments with agonists and antagonists of hypothalamic neuropeptides, currently available, on the development and treatment of adiposity and negative cross-talk between adiposity and muscle/bone tissue
Conditions
- Endocrine Disorders
- Adiposity
- Pituitary Adenoma
- Cushing Syndrome
- Acromegaly
- Hypopituitarism
Sponsors & Collaborators
-
IRCCS San Raffaele
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-07-31
- Primary Completion
- 2024-07-31
- Completion
- 2026-12-31
More Related Trials
-
Peri-operative Dynamics of the Growth Hormone Axis in Subjects With Acromegaly
NCT00921609 ·Status: COMPLETED
-
Muscle in Acromegaly and Cushing's Syndrome
NCT03673761 ·Status: UNKNOWN
-
Neuroendocrine Modulation of Metabolic Effects in Overweight Adolescents
NCT00140842 ·Status: COMPLETED
-
Effects of Pasireotide Lar Therapy on Bone Metabolism
NCT07179926 ·Status: RECRUITING
-
Prevalence and Cardiovascular Effects of Growth Hormone Deficiency in Abdominal Obesity
NCT00562796 ·Status: COMPLETED
-
Acylated Ghrelin Response to Acute Exercise in Obesity
NCT00486161 ·Status: COMPLETED
-
A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia
NCT00796783 ·Status: TERMINATED
-
Effects of Growth Hormone Administration on Cardiovascular Risk in Cured Acromegalics With Growth Hormone Deficiency
NCT00182091 ·Status: COMPLETED ·Phase: NA
-
Effect of Metyrapone on Cardiovascular Risk Factors in Patients With Adrenal Incidentalomas and Cushing's Syndrome
NCT06801249 ·Status: RECRUITING ·Phase: PHASE4
-
Cardiovascular Outcome After Surgery or Somatostatin Analogues
NCT00615004 ·Status: COMPLETED
-
Cushing's Disease Complications
NCT02568982 ·Status: COMPLETED
-
The Observational Study of Growth Hormone-secreting Pituitary Tumors
NCT01368133 ·Status: UNKNOWN
-
Cellular, Molecular and Clinical Determinants of Bone Strength in in Vivo and Human Models of GH Excess.
NCT06344650 ·Status: RECRUITING
-
Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT)
NCT00915954 ·Status: COMPLETED ·Phase: NA
-
Growth Hormone, Cardiovascular Risk, and Visceral Adiposity
NCT00131378 ·Status: COMPLETED ·Phase: NA
-
Efficacy of Octreotide Acetate and Cabergoline in Patients With Acromegaly
NCT00376064 ·Status: COMPLETED ·Phase: PHASE4
-
Evaluation of Patients With Endocrine-Related Conditions
NCT00005664 ·Status: TERMINATED
-
A Prospective Study of Outcome After Therapy for Acromegaly
NCT01809808 ·Status: COMPLETED
-
Seoul National University Pituitary Disease Cohort Study
NCT03474601 ·Status: UNKNOWN
-
Effect of 5 Years of GH Replacement on Atherosclerosis
NCT00462475 ·Status: COMPLETED
-
Pituitary Histopathology and Hyperprolactinaemia and Risk of Glucose Metabolic Disturbances in Acromegaly.
NCT02092129 ·Status: UNKNOWN
-
Metabolic Effects of GH and IGF-I in Growth Hormone Deficient(GHD) and Diabetes and Impaired Glucose Tolerance(IGT)
NCT01020955 ·Status: COMPLETED ·Phase: PHASE3
-
KETOgenic Diet Therapy in Patients With ACROmegaly
NCT06949891 ·Status: RECRUITING ·Phase: NA
-
Endocrine Cardiomyopathy in Cushing Syndrome: Response to Cyclic GMP PDE5 inhibitOrs
NCT02611258 ·Status: COMPLETED ·Phase: PHASE2
-
Growth Hormone, IGF-1 and Medical Treatment in Acromegaly: Are There Effects on Gut Hormone Physiology and Postprandial Substrate Metabolism?
NCT02152124 ·Status: COMPLETED