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Muscle in Acromegaly and Cushing's Syndrome

NCT03673761 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2019-02-25

No results posted yet for this study

Summary

Cushing's syndrome (CS) and acromegaly determine myopathy and muscle weakness which persist long-term after control of hormone excess. Fatty infiltration in skeletal muscle (myosteatosis) is associated with muscle atrophy, frailty, and increased morbidity and mortality in several human models. The study is aimed at evaluating muscle structure in patients with controlled CS and acromegaly, and correlate it with functional tests of muscle strength. In addition, circulating molecules potentially mediating persistent myopathy in these patients will also be assessed.

Conditions

Interventions

OTHER

MRI, dual-energy, x-ray absorptiometry, muscle ultrasounds, blood testing

3.Dixon, T2 mapping MRI microRNAs

Sponsors & Collaborators

  • Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-02-01
Primary Completion
2019-10-31
Completion
2020-01-31

Countries

  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03673761 on ClinicalTrials.gov