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A Prospective Study of Outcome After Therapy for Acromegaly

NCT01809808 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 280

Last updated 2025-08-26

No results posted yet for this study

Summary

The purpose of this study is to evaluate hormone values and other markers of disease activity in a cohort of patients with acromegaly at the time of diagnosis and then prospectively after surgical or other treatment. This study is designed to determine blood levels of growth hormone and related hormones and cardiovascular risk markers as well as signs and symptoms of the disease at diagnosis and how these parameters change over time after surgical or other therapy. The investigators will also obtain hormonal data in a group of 50 healthy subjects who will each be studied just once with an oral glucose tolerance test (OGTT). These data will provide a comparison group to the acromegaly subjects.

Conditions

Interventions

PROCEDURE

Surgery for acromegaly

(non-experimental) standard procedure

DRUG

Medications for acromegaly

(non-experimental) standard procedure

DIAGNOSTIC_TEST

Total body magnetic resonance imaging

Subjects will undergo total body MRI with spectroscopy of the muscle and liver before and 3-6 months, 12 and 24 months after surgery or medical therapy for acromegaly.

PROCEDURE

Adipose Tissue Biopsy

Subjects will undergo biopsy of subcutaneous adipose tissue before and 12 and 24 months after surgery or medical therapy for acromegaly.

Sponsors & Collaborators

Principal Investigators

  • Pamela U Freda, M.D. · Columbia University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2003-09-30
Primary Completion
2025-08-31
Completion
2025-08-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01809808 on ClinicalTrials.gov