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Extended Mesenteric Resection in Ileocecal Crohn's Disease.

NCT06324838 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 204

Last updated 2026-01-15

No results posted yet for this study

Summary

The EXCEED project aims to study the role of the mesentery in disease recurrence in Crohn's disease (CD), as evidence suggests that including the mesentery when doing ileocecal resections can significantly reduce recurrence rates. The EXCEED study is a blinded randomised clinical trial with 204 participants having ileocecal Crohn's disease requiring resection. Participants will undergo either "standard" mesocolic sparing resection or extended mesocolic resection to assess its impact on reducing recurrence at the anastomotic site. The primary endpoint is endoscopic recurrence 12 months postoperatively.

Additionally, the study aims to evaluate the efficacy of different surveillance modalities in detecting anastomotic site recurrence. These examinations will be conducted pre- and postoperatively for a cohort of 20 participants.

Through this study, we seek to understand the mesentery's role in Crohn's disease recurrence and identify effective non-invasive methods for postoperative monitoring.

Conditions

  • Crohn's Disease of Terminal Ileum

Interventions

PROCEDURE

Standard laparoscopic ileocecal resection

Participants will undergo standard mesocolic sparing resection.

PROCEDURE

Extended laparoscopic ileocecal resection

Extended mesocolic resection to assess its impact on reducing recurrence at the anastomotic site.

Sponsors & Collaborators

  • Odense University Hospital

    lead OTHER

Principal Investigators

  • Mark B Ellebæk, PhD · Surgical Research Unit, Odense University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-02-01
Primary Completion
2028-12-31
Completion
2029-06-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06324838 on ClinicalTrials.gov