MedTrace Logo

Pharmacological Modulation of Peripheral Nerve Excitability

NCT06312254 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2025-04-30

No results posted yet for this study

Summary

The present project is a human experimental study. The aim is to assess the pharmacologically modulated excitability of peripheral sensory nerves with a human experimental model.

The study measures the excitability of peripheral sensory nerves before and after application of different topical drugs (lidocaine (5%), phenytoin (10%),mepyramine (2%) and placebo).

Conditions

Interventions

DRUG

Topical lidocaine 5%

Drug is used to pharmacologically modulate peripheral sensory afferents

DRUG

Topical Phenytoin 10%

Drug is used to pharmacologically modulate peripheral sensory afferents

DRUG

Topical Mepyramine 2%

Drug is used to pharmacologically modulate peripheral sensory afferents

OTHER

Topical Placebo

Drug is used as control

Sponsors & Collaborators

  • Aalborg University

    lead OTHER

Principal Investigators

  • Trine Andresen, Post.Doc · Center for Neuroplasticity and Pain

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-04-09
Primary Completion
2024-12-02
Completion
2024-12-11

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06312254 on ClinicalTrials.gov