Peripheral neuropathy is a disorder of peripheral nerves causing numbness, pain, tingling, weakness, and autonomic dysfunction, with etiologies including diabetes, toxins, infections, and immune conditions.
The FDA has approved Lifyorli (relacorilant) plus nab-paclitaxel for platinum-resistant ovarian cancer based on trial data showing improved survival. Separately, the agency granted Breakthrough Therapy designation to Lilly's sofetabart mipitecan for the same condition, expediting development of the antibody-drug conjugate.
Phase III KEYNOTE-B15 trial demonstrates enfortumab vedotin plus pembrolizumab significantly improves event-free survival and pathologic complete response rates compared with cisplatin-based chemotherapy in muscle-invasive bladder cancer.
The FDA approved pembrolizumab in combination with paclitaxel, with or without bevacizumab, for adult patients with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal carcinoma whose tumors express PD-L1 (CPS ≥1).
Innovent Biologics has dosed the first participant in its pivotal Phase 3 HeriCare-Breast01 study evaluating IBI354, a HER2-targeted antibody-drug conjugate, as first-line treatment for unresectable locally advanced or metastatic HER2-positive breast cancer.
The FDA approved pembrolizumab (Keytruda) and Keytruda Qlex plus paclitaxel, with or without bevacizumab, for adults with PD-L1+ platinum-resistant ovarian carcinoma based on Phase 3 trial data showing improved survival outcomes.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07548476 |
Acupuncture and Exercise for EV-Pembro-Induced Peripheral Neuropathy |
NOT_YET_RECRUITING | NA |
| NCT07501663 |
Optimizing Integrative Oncology Approaches to Address Chemotherapy-induced Peripheral Neuropathy in Gastrointestinal (GI) Cancer Patients: A SMART Pilot Study |
RECRUITING | NA |
| NCT07475065 |
The Effect of Oral DLBS1033 in Patients With Diabetic Polyneuropathy |
NOT_YET_RECRUITING | PHASE2/PHASE3 |
| NCT07362147 |
Exploring the Effects of Hand and Foot Exercise Intervention in Older Adults With Gynecological Cancer Receiving Chemotherapy Improvement of Peripheral Neuropathy and Quality of Life |
NOT_YET_RECRUITING | NA |
| NCT07336381 |
Replexa+ Shortwave Diathermy Device for Patients Diagnosed With Peripheral Artery Disease and Peripheral Neuropathy |
RECRUITING | NA |
| NCT07321236 |
Effect of Hands and Feet Exercises on Taxane Based Chemotherapy Induced Peripheral Neuropathy in Patients With Solid Tumors |
NOT_YET_RECRUITING | NA |
| NCT07301892 |
Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis |
RECRUITING | |
| NCT07301177 |
DoD AtMS for Posttraumatic Peripheral Neuropathic Pain |
RECRUITING | NA |
| NCT07236515 |
Randomized, Sham-Controlled Investigation of the Leia Sensory Prosthesis in Individuals With Peripheral Neuropathy |
NOT_YET_RECRUITING | NA |
| NCT07172763 |
The Pressure Relieving Capacity of Siliconepads Compared to Felted Foam to Relieve Caput Metatarsal 2 in a Population With Diabetes |
NOT_YET_RECRUITING |
