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Peripheral Physiological Measures as Determinants of Pain Risk

NCT02985294 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2018-08-23

No results posted yet for this study

Summary

This study evaluates peripheral nervous system function using Multiple Excitability Measures (MEM) to obtain "electrophysiological pain phenotypes"

Conditions

  • Polyneuropathies
  • Peripheral Nerve Injuries
  • Peripheral Nervous System Diseases
  • Chemotherapy Effects
  • Neuralgia

Interventions

OTHER

Multiple Excitability Measures of peripheral nerves

The technique of threshold tracking can be used to obtain several measures of peripheral nerve excitability (Multiple Excitability Measures or MEM), such as refractoriness, supernormality, strength-duration time constant and 'threshold electrotonus' (i.e. the changes in threshold produced by long-lasting depolarizing or hyperpolarizing current pulses). Each of these measurements depends on membrane potential and on other biophysical properties of the axons. Many of these excitability parameters are very constant among different subjects, while other, such as the current/threshold parameters and the super/sub-excitability parameters, appear to be characteristic of an individual

Sponsors & Collaborators

  • University of Oxford

    collaborator OTHER

  • Institut National de la Santé Et de la Recherche Médicale, France

    collaborator OTHER_GOV

  • University of Aarhus

    collaborator OTHER

  • University of Dundee

    collaborator OTHER

  • Neuroscience Technologies SLP, Barcelona

    lead INDUSTRY

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-04-30
Primary Completion
2019-03-31
Completion
2020-04-30

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02985294 on ClinicalTrials.gov