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Effect of Methylcellulose or Psyllium on Fermentation of inUlin Assessed USing MRI

NCT06291272 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2024-08-12

No results posted yet for this study

Summary

The challenge is to understand how fibre interacts with whole-gut function to alter colonic fermentation of fermentable oligo-di- and mono-saccharides and polyhydric alcohols (FODMAPs). Studies will exploit the recent availability of a range of food grade modified celluloses which can form gels at body temperature to perform human studies to explore whether the beneficial effect of psyllium is unique or will be found with all gelling substances (4). The investigators are currently performing the COCOA2 study (Effect of modified cellulose on colonic fermentation of inulin) using a modified methylcellulose (results awaited). The investigators now wish to image what happens in the colon when methylcellulose is ingested to enable planning of the next step in the research programme.

Conditions

  • Colon, Irritable

Interventions

DIETARY_SUPPLEMENT

Psyllium

15 g psyllium + 15 g inulin

DIETARY_SUPPLEMENT

Methylcellulose

15 g methylcellulose + 15 g inulin

DIETARY_SUPPLEMENT

Inulin

15 inulin

DIETARY_SUPPLEMENT

Maltodextrin

15 maltodextrin

Sponsors & Collaborators

  • Quadram Institute Bioscience

    collaborator OTHER

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Robin Spiller, MD · Professor

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-15
Primary Completion
2024-06-30
Completion
2024-06-30

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06291272 on ClinicalTrials.gov