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Effects of Mediterranean Diet on Subjective Cognitive Decline

NCT06287489 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 57

Last updated 2025-09-09

No results posted yet for this study

Summary

Research Questions:

1. Due to the fact that most participants in past clinical trials on the Mediterranean diet were cognitively healthy individuals, and while the observed effects were significant, they were not particularly substantial, does the Mediterranean diet have similarly significant and more pronounced effects on both physical and cognitive functions in older adults with subjective cognitive decline (SCD)?
2. What is the mechanism behind the effects of the Mediterranean diet on physical or/and cognitive function? Is it through vascular protection or improvements in brain structure/brain network function?

Research Objective:

Conduct a cross-over randomized controlled trial to investigate the effects of a three-month Mediterranean diet on the physical and cognitive functions of older adults with subjective cognitive decline (SCD) in the community. Utilize brain MRI and circulatory biomarkers measurements to elucidate the underlying mechanisms.

Conditions

  • Subjective Cognitive Decline

Interventions

OTHER

Mediterranean diet

Mediterranean diet for three month

OTHER

Regular diet

regular diet

Sponsors & Collaborators

  • National Yang Ming Chiao Tung University

    collaborator OTHER

  • Chih-Ping Chung

    lead OTHER_GOV

Principal Investigators

  • Chih-Ping Chung, MD PhD · Department of Neurology, Neurological Institute, Taipei Veterans General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-10-26
Primary Completion
2024-12-02
Completion
2024-12-02

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06287489 on ClinicalTrials.gov