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Pathogenetic Risk Factors for Corneal Graft Rejection

NCT06281587 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 93

Last updated 2024-02-28

No results posted yet for this study

Summary

There are many predictors that may influence the development of corneal graft rejection after penetrating keratoplasty. In our study investigators analysed the results of keratoplasty and the risk factors for graft rejection.

Investigators analysed data from 493 patients who underwent penetrating keratoplasty between 2011 and 2019. Keratoplasty outcomes were followed up at subsequent clinic visits until December 2021. Then, 93 medical records were selected (taking into account the completeness of the medical records) and divided into two groups based on the primary diagnosis that was an indication for keratoplasty: high-risk and low-risk patients. Investigators then estimated the survival time (clear graft) of the corneal graft using Kaplan-Meier statistical survival analysis. Investigators also investigated the factors that influence corneal graft opacity.

Conditions

  • Graft Rejection

Interventions

PROCEDURE

penetrating keratoplasty

replacement of the affected tissue with healthy donor tissue in diseases that disrupt the shape or transparency of the cornea.

Sponsors & Collaborators

  • The S.N. Fyodorov Eye Microsurgery State Institution

    lead OTHER_GOV

Eligibility

Min Age
13 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-01-31
Primary Completion
2019-01-31
Completion
2019-01-31

Countries

  • Russia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06281587 on ClinicalTrials.gov