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Effects of Vitamin C on Skeletal Muscle

NCT06262711 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2024-02-16

No results posted yet for this study

Summary

As part of the ageing process muscles become weaker. One of the reasons for this is that mitochondria, the 'engines' that provide energy to fuel muscles, age and work less efficiently. Mitochondria are found in almost all cells in the human body. Mitochondria take in nutrients that are provided from food and break these down to create energy-rich compounds to fuel many different processes in the body. Muscles are loaded with mitochondria because they require a lot of energy. Mitochondria naturally produce small compounds called oxidants that can damage muscle cells and can cause inflammation. The cells in the body have a natural defence system to protect against oxidants, but when mitochondria age and become less efficient, the amount of oxidants that they produce can increase. These oxidants can damage muscles and the mitochondria themselves. Antioxidants, such as vitamin C, may help protect muscles from the damage caused by oxidants, and may help mitochondria work more efficiently. In this study, the investigators will explore whether vitamin C can help mitochondria work more efficiently, which may improve muscle strength, and help older people to remain mobile and independent for longer.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

Vitamin C

Vitamin C 500mg hydroxypropyl methylcellulose (HPMC) capsules (Solgar UK).

DIETARY_SUPPLEMENT

Placebo

Vitamin C-matched placebo capsule. Placebo capsules manufactured using hydroxypropyl methylcellulose (HPMC) capsules and microcrystalline cellulose (MCC).

Sponsors & Collaborators

  • The Norfolk and Norwich University Hospitals NHS Foundation Trust

    collaborator UNKNOWN

  • The Quadram Institute Clinical Research Facility

    collaborator UNKNOWN

  • University of East Anglia

    lead OTHER

Principal Investigators

  • Dr Max Yates · Norfolk and Norwich University Hospitals NHS Foundation Trust

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
65 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-02-29
Primary Completion
2025-03-31
Completion
2025-03-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06262711 on ClinicalTrials.gov