Effects of Railway Vibration on Sleep and Disease

Summary

This study will investigate the biological mechanisms linking sleep disruption by vibration and noise, and the development of cardiometabolic disease. In a laboratory sleep study, the investigators will play railway vibration of different levels during the night. The investigators will also measure objective sleep quality and quantity, cognitive performance across multiple domains, self-reported sleep and wellbeing outcomes, and blood samples. Blood samples will be analyzed to identify metabolic changes and indicators of diabetes risk in different nights. Identifying biomarkers that are impacted by sleep fragmentation will establish the currently unclear pathways by which railway vibration exposure at night can lead to the development of diseases in the long term, especially metabolic disorders including diabetes.

Conditions

• Noise Exposure
• Sleep Disturbance
• Sleep Hygiene
• Metabolic Disturbance
• Cognitive Change
• Glucose Metabolism Disorders (Including Diabetes Mellitus)
• Vibration; Exposure

Interventions

RADIATION

Railway noise

Low level railway noise, not exceeding 50 dB LAF,max. Thirty six single railway noise events.

RADIATION

Low level railway vibration

36 single railway noise events at 0.5 mm/s, varying from 11.5 s to 56.9 s in duration. Vibration always occurs concurrently with the noise exposure.

RADIATION

Intermediate level railway vibration

36 single railway noise events at 0.7 mm/s, varying from 11.5 s to 56.9 s in duration. Vibration always occurs concurrently with the noise exposure.

RADIATION

High level railway vibration

36 single railway noise events at 0.9 mm/s, varying from 11.5 s to 56.9 s in duration. Vibration always occurs concurrently with the noise exposure.

Sponsors & Collaborators

• University of Pennsylvania

  collaborator OTHER

• University of Manitoba

  collaborator OTHER

• Göteborg University

  lead OTHER

Principal Investigators

• Michael G Smith, PhD · Göteborg University

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

30 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-02-05

Primary Completion

2024-06-14

Completion

2024-10-31

Countries

• Sweden

Study Locations