Metabolic and Cognitive Consequences of Noise-induced Sleep Disturbance

Summary

This study will investigate the biological mechanisms linking sleep disruption by noise and the development of disease. In a laboratory sleep study, we will play traffic sounds of different types (road, rail and air) and noise levels during the night. We will also have nights with sound from so-called "white noise machines". These generate a low-level and continuous noise that may improve sleep by "masking" the traffic noises that would otherwise disturb sleep. We will also measure objective sleep quality and quantity, cognitive performance across multiple domains, self-reported sleep and wellbeing outcomes, and blood samples. Blood samples will be analysed to identify metabolic changes in different nights. Identifying biomarkers that are impacted by sleep fragmentation will establish the currently unclear pathways by which chronic noise exposure at night can lead to the development of diseases in the long term, especially cardiometabolic disorders.

Conditions

• Noise Exposure
• Sleep Disturbance
• Sleep Hygiene
• Metabolic Disturbance
• Cognitive Change

Interventions

RADIATION

Pink noise exposure

Continuous pink noise sound exposure at 45 dBA, throughout the whole night

RADIATION

Traffic noise

120 traffic noise events (40 each of road, rail and aircraft), introduced at maximum sound pressure levels ranging between 45-65 dB LAS.max.

Sponsors & Collaborators

• University of Pennsylvania

  collaborator OTHER

• University of Manitoba

  collaborator OTHER

• Göteborg University

  lead OTHER

Principal Investigators

• Michael G Smith, PhD · Göteborg University

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

30 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-04-24

Primary Completion

2022-06-03

Completion

2022-06-03

Countries

• Sweden

Study Locations