MedTrace Logo

Effect of Diluent Volume on Colistin Inhalation Therapy

NCT06230614 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-02-27

No results posted yet for this study

Summary

The aim of this study is to investigate the impact of different diluent volumes for the same dosage of colistin in mechanically ventilated respiratory patients receiving colistin inhalation therapy. The study aims to determine whether the diluent volume has an effect on clinical outcomes, including ICU length of stay, total hospitalization duration, duration of respiratory support within 28 days, mortality rates within 28 days and 90 days, as well as analyze the pharmacokinetic profile of colistin in blood and bronchoalveolar lavage fluid. Additionally, the study will evaluate the incidence of nebulizer malfunctions and blockages. The findings of this research will help identify the optimal diluent volume for colistin inhalation therapy in clinical practice.

Conditions

  • Inhalation Pneumonia

Interventions

OTHER

Colistin 1 MU in normal saline 1 ml

Colistin 1 MU diluted in normal saline 1 ml, total volume of 12 ml

OTHER

Colistin 1 MU in normal saline 2 ml

Colistin 1 MU diluted in normal saline 2 ml, total volume of 12 ml

Sponsors & Collaborators

  • Fu Jen Catholic University

    lead OTHER

Principal Investigators

  • Ke-Yun Chao, PhD · Fu Jen Catholic University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-03-10
Primary Completion
2026-07-31
Completion
2026-07-31

Countries

  • Taiwan

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06230614 on ClinicalTrials.gov