MedTrace Logo

Cardiovascular And Metabolic Risk After Arthroplasty

NCT06211465 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 152

Last updated 2024-01-18

No results posted yet for this study

Summary

Osteoarthritis is a chronic joint disease that lacks curative therapy. Epidemiological studies show increase in the burden of disease. Total joint arthroplasty is one of the best treatment options for end-stage osteoarthritis. However, the specific effects of total joint arthroplasty on cardiovascular risk and metabolic profile are largely unknown. The aim of this project is to elucidate how hip and knee total joint arthroplasty impacts cardiovascular risk and metabolomic profile in comparison with general population. We hypothesize that arthroplasty decreases pain, systemic inflammation levels and increases functional status that all lead to decreased metabolic and cardiovascular risk.

Conditions

Interventions

PROCEDURE

Total joint arthroplasty

Hip or knee total joint arthroplasty

Sponsors & Collaborators

  • Tartu University Hospital

    collaborator OTHER

  • Estonian Science Foundation

    collaborator OTHER_GOV

  • University of Tartu

    lead OTHER

Principal Investigators

  • Kaspar Tootsi, PhD, MD · University of Tartu

  • Kadri Vilba, MD · University of Tartu

  • Aare Märtson, PhD, MD · University of Tartu

  • Jaak Kals, PhD, MD · University of Tartu

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-03-01
Primary Completion
2023-01-31
Completion
2023-04-30

Countries

  • Estonia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06211465 on ClinicalTrials.gov