Neurotoxicity and Cardiotoxicity in Total Joint Arthroplasty

Summary

The purpose of this research is to understand whether patients who previously had total hip or total knee replacement experience memory, thinking or heart problems. This study will help us determine if and how often these problems occur.

Conditions

• Metallosis
• Pain
• Total Hip Replacement
• Total Knee Replacement

Interventions

BEHAVIORAL

Questionnaires

You will be asked to complete a questionnaire about your family history of neurological diseases and current and past physical thinking activities.

BEHAVIORAL

Interviews

Behavioral and Memory interviews will take place with the patient.

OTHER

Blood draw

Have a sample of blood drawn (4.2-5 tablespoons) for clinical and research tests.

RADIATION

Magnetic Resonance Imaging

Each MR examination takes about 45 minutes and does not require the use of needles, medication or contrast enhancement. You will lie on your back and enter the MR scanner for the study, during which time you will hear knocking noises. People with pacemakers, aneurysm clips, cochlear implants, or metal/foreign objects in their eyes are not permitted to undergo MR studies. We will review your implants and determine your eligibility.

DIAGNOSTIC_TEST

Echocardiogram

Each echocardiogram takes about 30 minutes. This test uses sound waves to look at your heart. The person doing the test will press on your chest with a machine to obtain the pictures. The pressure may be uncomfortable. The echocardiogram will involve an image enhancement agent infusion to obtain better images.

Sponsors & Collaborators

• National Institute on Aging (NIA)

  collaborator NIH

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Mayo Clinic

  lead OTHER

Principal Investigators

• Hilal Maradit Kremers, MD · Principal Investigator

Eligibility

Min Age

18 Years

Max Age

100 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-10-01

Primary Completion

2021-09-27

Completion

2021-09-27

Countries

• United States

Study Locations