MedTrace Logo

Tolerance in Beekeepers

NCT06156046 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2025-04-30

No results posted yet for this study

Summary

Beekeepers experience multiple bee stings each year. Many of these beekeepers (25-60%) become sensitized to bee venom through the production of specific antibodies that target the bee venom. Although these antibodies are important in the triggering of an allergic reaction only a small number of sensitised beekeepers go on to have an allergic reaction with symptoms away from the site of the sting. These reactions can be severe and are known as anaphylactic reactions.

The study investigates why some beekeepers develop severe allergic symptoms after bee stings while others do not.

This study will explore factors in the blood that protect sensitised individuals from having anaphylactic reactions - meaning that despite being sensitised they are tolerant and do not react to subsequent stings.

Conditions

  • Bee Sting

Interventions

DIAGNOSTIC_TEST

skin prick test

Skin prick test for bee venom

DIAGNOSTIC_TEST

Blood tests

IgE/G and T cell tolerance studies

Sponsors & Collaborators

  • University of Plymouth

    collaborator OTHER

  • University Hospital Plymouth NHS Trust

    lead OTHER

Principal Investigators

  • Claire Bethune · University Hospitals Plymouth

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-01-22
Primary Completion
2027-10-01
Completion
2027-10-01

Countries

  • United Kingdom

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06156046 on ClinicalTrials.gov