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Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement

NCT06149585 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 12

Last updated 2025-06-04

No results posted yet for this study

Summary

The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in subjects affected by severe periodontitis; to evaluate if microbiome changes in relation to the used of different implant material/surface; and to assess the variance of the changes to determine the sample size for future longitudinal prospective studies.

Conditions

  • Edentulous Mouth
  • Periodontal Diseases
  • Periodontitis, Adult
  • Microbial Colonization

Interventions

OTHER

Microbial Sampling

Pool microbial sampling will be performed and changes in the microbiome will be evaluated and compared for differences

Sponsors & Collaborators

  • Case Western Reserve University

    lead OTHER

Principal Investigators

  • Gian Pietro Schincaglia, DDS,PhD · Case Western Reserve University

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-08-16
Primary Completion
2026-05-01
Completion
2027-05-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06149585 on ClinicalTrials.gov